c difficile organism

Clostridium difficile Photo credit: CDC/ James Archer

Ascenda BioSciences is proud to introduce a NEW molecular stool test that detects C. diff toxin A and B (2 separate results).   This test is intended for all types of patients with diarrhea, especially those who live in assisted living facilities

Gastrointestinal infections in both pediatric and adult patients account for significant morbidity and mortality worldwide (Schlenker and Surawicz 2009). In developing countries, an estimated two to four billion episodes of infectious diarrhea occur annually (Navaneethan and Giannella 2008). In addition, immunocompromised hosts, including HIV patients, solid-organ transplant recipients or patients requiring therapy for chronic inflammatory diseases are susceptible to gastrointestinal infections (Thom and Forrest 2006). Mild diarrhea can lead to absenteeism from school or work and may require treatment by a health care provider. Patients with severe diarrhea may be hospitalized and some may develop more serious sequelae such as Guillain Barré syndrome and hemolytic uremic syndrome (HUS), and in some cases death (Fischer Walker, Sack et al. 2010). Nearly three percent of neonatal mortality and 17 percent of under-five child mortality is attributable to diarrhea (Patel, Mamtani et al. 2010).

Clostridium difficile is the most common cause of nosocomial infectious diarrhea in developed countries and is the major cause of antibiotic-associated pseudomembranous colitis (Yoo and Lightner 2010; Navaneethan and Giannella 2008). C. difficile is a Gram-positive anaerobic rod-shaped bacterium belonging to the Clostridiaceae family that causes diarrhea following the production of two toxins, enterotoxin A (the product of the tcdA gene) and cytotoxin B (the product of the tcdB gene) (Yoo and Lightner 2010; Schlenker and Surawicz 2009; Persson, Torpdahl et al. 2008). In the US, the number of hospitalized patients discharged with “intestinal infection due to C. difficile” (as the discharge diagnosis) more than doubled between 2000 and 2009 from approximately 139,000 to 336,000 (CDC, 2012).

Check out the details on our test menu page and contact us today for more information about how to order the test.

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