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Ascenda BioSciences offers unique stool testing and biopsy panels, providing 28+ analytes. Our panels provide results for analytes individually, bundled, or comprehensively. 

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Stool testing & Biopsy Sample report

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The GIP Panel includes 22 unique markers: bacteria, parasites, and viruses.

GIP Panel (Bacteria, Parasites, and Viruses)

Our multiplexed nucleic acid testing verifies the existence of pathogens with one stool specimen in a singular stool test.

Bacteria

  • Campylobacter
  • Clostridium difficile toxin A/B
  • E. coli O157
  • Plesiomonas shigelloides
  • Salmonella
  • Vibrio
  • Vibrio cholerae
  • Yersinia enterocolitica

Diarrheagenic E. coli/Shigella

  • Enteroaggregative E. coli (EAEC)
  • Enteropathogenic E. coli (EPEC)
  • Enterotoxigenic E. coli (ETEC) lt/st
  • Shiga-like Toxin E. coli (STEC) stx 1/ stx 2
  • Shigella/Enteroinvasive E. coli (EIEC)

Parasites

  • Cryptosporidium
  • Cyclospora cayetanensis
  • Entamoeba histolytica
  • Giardia

Viruses

  • Adenovirus F 40/41
  • Astrovirus
  • Norovirus GI/GII
  • Rotavirus A
  • Sapovirus

The GIP is a multiplexed nucleic acid test that is designed to identify numerous bacteria, parasites and viruses in the digestive system. Using molecular technology, this panel has the capability of detecting multiple pathogens and parasites within a single stool test run and offers the provider the highest standard of testing. The GIP test simultaneously detects and identifies the organisms responsible for over 95% of cases of infectious diarrhea. Indicated uses for GIP: Acute and chronic diarrhea. All patients with symptoms and signs of infectious gastroenteritis or colitis. Inpatient, outpatient and emergency settings Nosocomial surveillance

Specimen: Stool Sample

Collection and transportation

Stool sample collected by the patient or client and transported in the provided Fecal Swab vial at room temperature.

Methodology

Multiplex PCR (polymerase chain reaction) and melt curve analysis. When ordering the GIP test, you will receive a complete, easy to use stool testing collection kit that you return, postage-paid (US only), with your stool specimen. We process your specimen the same day of receipt in our state-of-the-art facility and provide your test results directly to your physician, usually within 1 to 2 business days. Please contact us at customerservice@ascendabio.com or at (855)374-5227 – option 2.

CPT Code: 87506

Infectious agent detection by nucleic acid (DNA or RNA); gastrointestinal pathogen (eg, Clostridium difficile, E. coli, Salmonella, Shigella, norovirus, Giardia), includes multiplex reverse transcription, when performed, and multiplex amplified probe technique, multiple types or subtypes, 6-11 targets.

CPT Code: 87507

Infectious agent detection by nucleic acid (DNA or RNA); gastrointestinal pathogen (eg, Clostridium difficile, E. coli, Salmonella, Shigella, norovirus, Giardia), includes multiplex reverse transcription, when performed, and multiplex amplified probe technique, multiple types or subtypes, 12-25 targets.

ICD-10 Code Description
A02.0 Salmonella enteritis
A03.0 Shigellosis due to Shigella dysenteriae
A04.0 Enteropathogenic Escherichia coli
A04.72 Enterocolitis due to Clostridium diff
A07.1 Giardiasis [lambliasis]
K52.9 Noninfective gastroenteritis and colitis

Helicobacter (H.Pylori) Panel

Our PCR based biopsy testing detection of Helicobacter pylori can serve as a powerful tool in diagnosis of Helicobacter pylori infection, and as a determinant for treatment efficacy.

  • Helicobacter pylori (H. pylori)

Culture testing is one of the methods that allows researchers and clinicians to identify H. pylori in small biopsy testing samples that have few bacteria present. PCR can be performed faster than many other diagnostic methods, used to identify diverse bacterial genotypes, and employed in epidemiological studies. A considerable drawback of PCR is that it can detect DNA segments of dead bacterium in the gastric mucosa of patients after treatment; consequently, it cannot differentiate between a live and dead microorganism.

Molecular detection of H. pylori using PCR testing on DNA extracted from biopsy specimens is an accurate and time sensitive means for diagnosis. Molecular testing may be of particular value for samples that can no longer be successfully cultured because of prolonged transport or in cases where isolation of H. pylori is not feasible as a result of contamination.

When ordering the H. pylori test, you will receive a complete, easy to use collection kit that you return, postage-paid (US only). We process your specimen as soon as it is received in our state-of-the-art facility and provide your test results directly to your physician, usually within three to four business days. Please contact us at customerservice@ascendabio.com or at (855)374-5227 – option 2.

CPT Code: 87338 – Detect agent nos dna amp (H. pylori)

ICD-10 Code Description
K27.0 Acute peptic ulcer, site unspecified, with hemorrhage
K27.1 Acute peptic ulcer, site unspecified, with perforation
K27.2 Acute peptic ulcer, site unspecified, with both hemorrhage and perforation
K27.3 Acute peptic ulcer, site unspecified, without hemorrhage or perforation
K27.4 Chronic or unspecified peptic ulcer, site unspecified, with hemorrhage
K27.5 Chronic or unspecified peptic ulcer, site unspecified, with perforation
K27.6 Chronic or unspecified peptic ulcer, site unspecified, with both hemorrhage and perforation
K27.7 Chronic peptic ulcer, site unspecified, without hemorrhage or perforation
K27.9 Peptic ulcer, site unspecified, unspecified as acute or chronic, without hemorrhage or perforation
K29.0 Acutegastritis
K29.00 Acute gastritis without bleeding
K29.01 Acute gastritis with bleeding
K29.2 Alcoholic gastritis
K29.20 Alcoholic gastritis without bleeding
K29.21 Alcoholic gastritis with bleeding
K29.3 Chronic superficial gastritis
K29.4 Chronic atrophic gastritis
K29.5 Unspecified chronic gastritis
K29.6 Othergastritis
K29.7 Gastritis,unspecified
K29.8 Duodenitis
K29.9 Gastroduodenitis,unspecified
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The HP Panel does biopsy samples solely for H. Pylori.

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The C.Diff Panel detects toxin A positive, toxin B positive, or both strains positive.

C. Difficile ONLY, Panel

Our C. difficile only stool testing assay specifically detects toxin A positive or toxin B positive strains or both.

  • C. difficile toxin A
  • C. difficile toxin B

We test for Clostridium difficile using two molecular methodologies. First is the multiplex assay platform (see GIP Panel), that is designed to test for many GI pathogens (including C.difficile), parasites and viruses using multiplex PCR and melt curve analysis from patient stool samples. The second test is a C. difficile only assay, that specifically targets the C. difficile toxin A gene (tcdA) and toxin B gene (tcdB) with real-time PCR chemistry and is able to detect the presence of this bacterium from stool samples in just a few hours.

With the C. difficile only Assay, we are able to specifically detect toxin A positive or toxin B positive strains or both. In house comparison studies have shown good correlation between the two methodologies in detecting C. difficile from patient stool testing samples. The two platforms of molecular testing allow for flexibility: 1) if the doctor requires only C. difficile testing or 2) a more expanded panel of analytes to be tested for a patient, they will able choose the platform to meet their requirements. The C. difficile only Assay will also be offered as a reflex test to a positive C. difficile identification in the GIP panel.

When ordering the C. difficile only test, you will receive a complete, easy to use collection kit that you return, postage-paid (US only), with your stool specimen. We process your specimen as soon as it is received in our state-of-the-art facility and provide your test results directly to your physician, usually within three to four business days. Please contact us at customerservice@ascendabio.com or at (855)374-5227 – option 2.

CPT Code: 87493 – C diff amplified probe (MUE-2)

ICD-10 Code Description
A04.71 Enterocolitis due to Clostridium difficile, recurrent
A04.72 Enterocolitis due to Clostridium difficile, not specified as recurrent
Z11.0 Encounter for screening for intestinal infectious Diseases
Z11.2 Encounter for screening for other bacterial Diseases

Antibiotic Resistance Panel

The antibiotic resistance panel will be offered as a reflex test upon a positive bacterial identification in the GIP test.

  • ß-lactamase (bla-TEM)
  • Nitroimidazole (nimD)
  • Imidazole (nimA)
  • Vancomycin (vanA)
  • Vancomycin (vanB)
  • Fluoroquinolones (qnr)
Susceptibility to antimicrobial agents is typically determined by phenotypic methods. The phenotypic development of resistance is detected by performing in vitro susceptibility testing. Testing for altered sensitivity to antimicrobial agents is of clinical significance especially when organisms persists in patients being treatment with antimicrobial agents that are generally considered effective against particular isolate. At Ascenda BioSciences we assess antibiotic resistant genes in patient stool samples using molecular methods that that detect genes directly involved in the resistance of an organism to a particular agent and offer a more straightforward prediction of antibiotic resistance.
The AR panel will be offered as a reflex test to a positive bacterial identification using the GIP test. This test cannot be ordered as a standalone test.

CPT Code: 87798 – Detect agent nos dna amp MUE(6)

ICD-10 Code Description
Z16.12 Extended spectrum beta lactamase (ESBL) resistance
Z16.19 Resistance to other specified beta lactam antibiotics
Z16.21 Resistance to vancomycin
Z16.22 Resistance to vancomycin related antibiotics
Z16.23 Resistance to quinolones and fluoroquinolones
Z16.24 Resistance to multiple antibiotics
Z16.29 Resistance to other single specified antibiotic
Z16.31 Resistance to antiparasitic drug(s)
Z16.32 Resistance to antifungal drug(s)
Z16.33 Resistance to antiviral drug(s)
Z16.34 Resistance to antimycobacterial drug(s)
Z16.341 Resistance to single antimycobacterial drug
Z16.342 Resistance to multiple antimycobacterial drugs
Z16.35 Resistance to multiple antimicrobial drugs
Z16.39 Resistance to other specified antimicrobial drug
Z16.12 Extended spectrum beta lactamase (ESBL) resistance

The AR Panel looks for Antibiotic resistance associate with bacteria identified using the GIP panel.

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The GHM Panel looks for GHM's only. This panel encompasses a wide variety of markers.

GI Health Markers Panel

Our GI inflammatory health markers stool testing provides detailed information about possible inflammation that could occur in the digestive system. These markers are especially helpful in determining IBS or IBD. We also offer H.pylori stool antigen test that detects the presence of possible H.pylori infection.

Our GI inflammatory health markers are an invaluable resource for providers to determine the patient’s condition of Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD). IBS and IBD are both chronic illnesses and share many of the same symptoms, however, each is treated differently. If not diagnosed correctly, serious effects could arise from both illnesses. Providers can select from our complete offering of protein markers to fully understand if inflammation exists throughout the entire digestive system.

If providers are concerned with specific areas within the digestive system, individual markers can be selected for precise inflammation detection. These markers provide an abundance of information and has the highest sensitivity and specificity results of any digestive test available. When ordering the GI Health Markers test, you will receive a complete, easy to use collection kit that you return, postage-paid (US only), with your stool specimen.

We process your specimen as soon as it is received in our state-of-the-art facility and provide your test results directly to your physician, usually within three to four business days. Please contact us at customerservice@ascendabio.com or at (855)374-5227 – option 2.

CPT Codes

  • Anti-gliadin: 82784
  • Calprotectin: 83993
  • Fecal Fat: 83690
  • Fecal Occult Blood: 82274
  • H. pylori stool antigen: 87739
  • Lactoferrin: 83361
  • Pancreatic Elastase: 82656
ICD-10 Code Description Associated Test
A04.7 Clostridium difficile Lactoferrin
K51.80 Ulcerative colitis Lactoferrin
K58.0 Irritable Bowel Syndrome Calprotectin
K50.90 Crohn’s disease Calprotectin
K90.0 Celiac disease Anti-Gliadin/Fecal Fat
K90.41 Non-celiac gluten sensitivity Anti-Gliadin/Fecal Fat
K29.0 Acute gastritis with bleeding H. Pylori SA
K27.0 Acute peptic ulcer, site unspecified H. Pylori SA
K80.10 Exocrine pancreatic insufficiency Elastase
K85.10 Other specified diseases of pancreas Elastase

The Full Panel includes the GIP and GI Health Markers. C. Diff A/B and AR will be reflex tests for GIP panel.

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